Journal article
Role of Dicer in posttranscriptional RNA silencing.
- Jaskiewicz L Friedrich Miescher Institute for Biomedical Research, 4002 Basel, Switzerland.
- Filipowicz W
- 2008-02-14
Published in:
- Current topics in microbiology and immunology. - 2008
Animals
Humans
RNA Interference
RNA, Double-Stranded
RNA, Messenger
RNA-Induced Silencing Complex
Ribonuclease III
English
Dicer, an RNase III type endonuclease, is the key enzyme involved in RNA interference (RNAi) and microRNA (miRNA) pathways. It is required for biogenesis of miRNAs and small interfering RNAs (siRNAs), and also plays an important role in an effector step of RNA silencing, the RNA-induced silencing complex (RISC) assembly. In this article we describe different functions of Dicer in posttranscriptional regulation. We review the current knowledge about Dicers in different organisms and the functions of individual domains of the enzyme. We also discuss information about Dicer-associated proteins and their role in the biogenesis of small RNAs and assembly of RISC.
- Language
-
- English
- Open access status
- closed
- Identifiers
-
- DOI 10.1007/978-3-540-75157-1_4
- PMID 18268840
- Persistent URL
- https://roar.hep-bejune.ch/global/documents/12353
Statistics
Document views: 10
File downloads: