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Intussusception in children aged under two years in India: Retrospective surveillance at nineteen tertiary care hospitals.
Journal article

Intussusception in children aged under two years in India: Retrospective surveillance at nineteen tertiary care hospitals.

  • Das MK The INCLEN Trust International, New Delhi, India. Electronic address: manoj@inclentrust.org.
  • Arora NK The INCLEN Trust International, New Delhi, India. Electronic address: nkarora@inclentrust.org.
  • Gupta B The INCLEN Trust International, New Delhi, India. Electronic address: drbini.gupta02@gmail.com.
  • Sharan A The INCLEN Trust International, New Delhi, India. Electronic address: apoorva@inclentrust.org.
  • Kameswari K Andhra Medical College, Vishakhapatnam, Andhra Pradesh, India. Electronic address: kameswari1956@gmail.com.
  • Padmalatha P Andhra Medical College, Vishakhapatnam, Andhra Pradesh, India. Electronic address: padmap_2000@yahoo.com.
  • Prasad GR Andhra Medical College, Vishakhapatnam, Andhra Pradesh, India. Electronic address: dr.grajendraprasad@gmail.com.
  • Shad J Apollo Hospitals, Chennai, Tamil Nadu, India. Electronic address: shadjimmy@yahoo.co.in.
  • Shyamala J Apollo Hospitals, Chennai, Tamil Nadu, India. Electronic address: jaymoorthy@hotmail.com.
  • Harish Kumar S Apollo Hospitals, Chennai, Tamil Nadu, India. Electronic address: drharishkumar.s@gmail.com.
  • Nagender Y Apollo Hospital, Hyderabad, Telengana, India. Electronic address: yogimamidi@yahoo.com.
  • Sharmila K Apollo Hospital, Hyderabad, Telengana, India. Electronic address: sharmilakaza@gmail.com.
  • Shad R Choithram Hospital and Research Centre, Indore, Madhya Pradesh, India. Electronic address: drrashmishad@yahoo.com.
  • Garge S Choithram Hospital and Research Centre, Indore, Madhya Pradesh, India. Electronic address: saurabhgarge8@gmail.com.
  • Bharadia L Fortis Escorts Hospital, Jaipur, Rajasthan, India. Electronic address: lalitbharadia@gmail.com.
  • Gupta A Fortis Escorts Hospital, Jaipur, Rajasthan, India. Electronic address: atul.gupta1@fortishealthcare.com.
  • Goswami JK Gauhati Medical College, Guwahati, Assam, India. Electronic address: jayantagoswami@hotmail.com.
  • Lahiri K Gauhati Medical College, Guwahati, Assam, India. Electronic address: Kaushik_1671979@rediffmail.com.
  • Sankhe L Grant Medical College & JJ Hospital, Mumbai, Maharashtra, India. Electronic address: sankhelalit@yahoo.com.
  • Mane S Grant Medical College & JJ Hospital, Mumbai, Maharashtra, India. Electronic address: drsush2006@gmail.com.
  • Patwari YP Grant Medical College & JJ Hospital, Mumbai, Maharashtra, India. Electronic address: patwariyogini@gmail.com.
  • Ajayakumar MK Government Medical College & SAT Hospital, Thiruvananthapuram, Kerala, India. Electronic address: drajaykumarmk@gmail.com.
  • Santhosh Kumar A Government Medical College & SAT Hospital, Thiruvananthapuram, Kerala, India. Electronic address: hod.pediatrics.sath@gmail.com.
  • Sarangi R IMS & SUM Medical College & Hospital, Bhubaneswar, Odisha, India. Electronic address: rachitapaedia@gmail.com.
  • Tripathy BB IMS & SUM Medical College & Hospital, Bhubaneswar, Odisha, India. Electronic address: bbtripathy.dr@gmail.com.
  • Mohapatra SSG IMS & SUM Medical College & Hospital, Bhubaneswar, Odisha, India. Electronic address: drartifact@gmail.com.
  • Sahoo SK IMS & SUM Medical College & Hospital, Bhubaneswar, Odisha, India. Electronic address: dr_subratsahoo@yahoo.com.
  • Kumar V Indira Gandhi Institute of Medical Sciences, Patna, Bihar, India. Electronic address: drvijayendrakr@rediffmail.com.
  • Kumar R Indira Gandhi Institute of Medical Sciences, Patna, Bihar, India. Electronic address: drjaiswalrakesh@gmail.com.
  • Sarkar S Institute of Post Graduate Medical Education and Research, Kolkata, West Bengal, India. Electronic address: dr.sumansarkar@gmail.com.
  • Sarkar R Institute of Post Graduate Medical Education and Research, Kolkata, West Bengal, India. Electronic address: ruchirendu@gmail.com.
  • Sarkar NR Institute of Post Graduate Medical Education and Research, Kolkata, West Bengal, India. Electronic address: dr.niharsarkar@gmail.com.
  • Wakhlu A King George's Medical University, Lucknow, Uttar Pradesh, India. Electronic address: ashish_wakhlu@hotmail.com.
  • Ratan SK Maulana Azad Medical College, Delhi, India. Electronic address: drjohnsimmi@yahoo.com.
  • Dubey AP Maulana Azad Medical College, Delhi, India. Electronic address: Anand_dubey52@hotmail.com.
  • Mohan N Medanta- The Medicity, Gurgaon, Haryana, India. Electronic address: drneelam@yahoo.com.
  • Luthra M Medanta- The Medicity, Gurgaon, Haryana, India. Electronic address: meera.luthra@medanta.org.
  • Vyas BR MP Shah Government Medical College, Jamnagar, Gujarat, India. Electronic address: bhadreshrvyas@yahoo.co.uk.
  • Trivedi H MP Shah Government Medical College, Jamnagar, Gujarat, India. Electronic address: trivediharsh@indiatimes.com.
  • Mathai J PSG Institute of Medical Sciences, Coimbatore, Tamil Nadu, India. Electronic address: psg_peds@yahoo.com.
  • Sam CJ PSG Institute of Medical Sciences, Coimbatore, Tamil Nadu, India. Electronic address: cenitasivamani@yahoo.com.
  • Jothilakshmi K PSG Institute of Medical Sciences, Coimbatore, Tamil Nadu, India. Electronic address: drjothi.cbe@gmail.com.
  • Arunachalam P PSG Institute of Medical Sciences, Coimbatore, Tamil Nadu, India. Electronic address: pavai4321@yahoo.com.
  • Bhat JI Sher-i-Kashmir Institute of Medical Sciences, Srinagar, Jammu & Kashmir, India. Electronic address: drjaveediqbal@gmail.com.
  • Mufti G Sher-i-Kashmir Institute of Medical Sciences, Srinagar, Jammu & Kashmir, India. Electronic address: gowharmufti@yahoo.co.in.
  • Charoo BA Sher-i-Kashmir Institute of Medical Sciences, Srinagar, Jammu & Kashmir, India. Electronic address: charoobash@gmail.com.
  • Jena PK SCB Medical College and SVP Postgraduate Institute of Paediatrics, Cuttack, Odisha, India. Electronic address: drpkjena@gmail.com.
  • Debbarma SK Agartala Government Medical College, Agartala, Tripura, India. Electronic address: dr_sanjibdb@rediffmail.com.
  • Ghosh SK Agartala Government Medical College, Agartala, Tripura, India. Electronic address: sunilkrghosh752@gmail.com.
  • Aggarwal MK Ministry of Health & Family Welfare, Government of India, New Delhi, India. Electronic address: drmkagarwal2@gmail.com.
  • Haldar P Ministry of Health & Family Welfare, Government of India, New Delhi, India. Electronic address: pradeephaldar@yahoo.co.in.
  • Zuber PLF World Health Organization, Geneva, Switzerland. Electronic address: zuberp@who.int.
  • Maure C World Health Organization, Geneva, Switzerland. Electronic address: maurec@who.in.
  • Bonhoeffer J University of Basel Children's Hospital, Basel, Switzerland. Electronic address: jan.bonhoeffer@gmail.com.
  • Ray A Bill and Melinda Gates Foundation, India Country Office, New Delhi, India. Electronic address: arindam.ray@gatesfoundation.org.
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  • 2020-06-20
Published in:
  • Vaccine. - 2020
Children
Epidemiology
India
Intussusception
Retrospective surveillance
English OBJECTIVE
Intussusception has been linked with rotavirus vaccine (RVV) as a rare adverse reaction. In view of limited background data on intussusception in India and in preparation for RVV introduction, a surveillance network was established to document the epidemiology of intussusception cases in Indian children.


METHODS
Intussusception in children 2-23 months were documented at 19 nationally representative sentinel hospitals through a retrospective surveillance for 69 months (July 2010 to March 2016). For each case clinical, hospital course, treatment and outcome data were collected.


RESULTS
Among the 1588 intussusception cases, 54.5% were from South India and 66.3% were boys. The median age was 8 months (IQR 6, 12) with 34.6% aged 2-6 months. Seasonal variation with higher cases were documented during March-June period. The most common symptoms and signs were vomiting (63.4%), bloody stool (49.1%), abdominal pain (46.9%) and excessive crying (42.8%). The classical triad (vomiting, abdominal pain, and blood in stools) was observed in 25.6% cases. 96.4% cases were diagnosed by ultrasound with ileocolic location as the commonest (85.3%). Management was done by reduction (50.8%) and surgery (41.1%) and only 1% of the patients' died. 91.1% cases met Brighton criteria level 1 and 3.3% Level 2. Between 2010 and 2015, the case load and case ratio increased across all regions.


CONCLUSION
Intussusception cases have occurred in children across all parts of the country, with low case fatality in the settings studied. The progressive rise cases could indicate an increasing awareness and availability of diagnostic facilities.
Language
  • English
Open access status
hybrid
Identifiers
Persistent URL
https://roar.hep-bejune.ch/global/documents/136817
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