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Acute Responses of Novel Cardiac Biomarkers to a 24-h Ultra-Marathon.

  • Żebrowska A Department of Physiological and Medical Sciences, Academy of Physical Education, Mikołowska Street 72a, 40-065 Katowice, Poland. a.zebrowska@awf.katowice.pl.
  • Waśkiewicz Z Department of Team Sports Games, Academy of Physical Education in Katowice, Mikołowska Street 72a, 40-065 Katowice, Poland. z.waskiewicz@awf.katowice.pl.
  • Nikolaidis PT Laboratory of Exercise Testing, Hellenic Air Force Academy, Dekelia, Thermopylon 7, 18450 Nikaia, Greece. pademil@hotmail.com.
  • Mikołajczyk R Department of Physiological and Medical Sciences, Academy of Physical Education, Mikołowska Street 72a, 40-065 Katowice, Poland. r.mikolajczyk@awf.katowice.pl.
  • Kawecki D Second Department of Cardiology, School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia, Skłodowskiej, Curie 10 Street, 41-800 Zabrze, Poland. d.kawecki@sum.edu.pl.
  • Rosemann T Institute of Primary Care, University of Zurich, 8091 Zurich, Switzerland. thomas.rosemann@usz.ch.
  • Knechtle B Institute of Primary Care, University of Zurich, 8091 Zurich, Switzerland. beat.knechtle@hispeed.ch.
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  • 2019-01-11
Published in:
  • Journal of clinical medicine. - 2019
human performance
myocardium ischemia
ultra-endurance
English The aim of the present study was to examine the acute effect of an ultra-endurance performance on N-terminal pro-brain natriuretic peptide (NT-proBNP), cardiac specific troponin T (cTnT), creatinine kinase-myocardial band (CK-MB), high sensitive C-reactive protein (hsCRP), ischemia modified albumin (IMA), heart-type fatty acid binding protein (H-FABP) and cardiovascular function. Cardiac biomarkers were evaluated in 14 male ultra-marathoners (age 40 ± 12 years) during a 24 h ultra-marathon at five points (i.e., Pre-race; Marathon, 12-h run, 24-h run, and 48-h post-race). All subjects underwent baseline echocardiography assessment at least 10 days prior to the ultra-marathon and 48 h post-race. The average distance covered during the race was 149.4 ± 33.0 km. Running the ultra-marathon led to a progressive increase in hsCRP and H-FABP concentrations (p < 0.001). CK-MB and cTnT levels were higher after a 24-h run compared to pre-race (p < 0.05). Diastolic function was altered post-race characterized by a reduction in peak early to late diastolic filling (p < 0.01). Running an ultra-marathon significantly stimulates specific cardiac biomarkers; however, the dynamic of secretion of biomarkers linked to myocardium ischemia were differentially regulated during the ultra-marathon race. It is suggested that both exercise duration and intensity play a crucial role in cardiovascular adaptive mechanisms and cause risk of cardiac stress in ultra-marathoners.
Language
  • English
Open access status
gold
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https://roar.hep-bejune.ch/global/documents/174944
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