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[CD34+ cell selection methods, quality controls and expected results: Guidelines from the Francophone Society of Bone Marrow Transplantation and Cellular Therapy (SFGM-TC)].
Journal article

[CD34+ cell selection methods, quality controls and expected results: Guidelines from the Francophone Society of Bone Marrow Transplantation and Cellular Therapy (SFGM-TC)].

  • Calmels B Centre de thérapie cellulaire, institut Paoli-Calmettes, 13009 Marseille, France.
  • Gautier É EFS Île-de-France, unité d'ingénierie et de thérapie cellulaire, 94017 Créteil, France.
  • Magnani A Hôpital Necker-Enfants Malades, laboratoire de thérapie cellulaire génique, 75015 Paris, France.
  • Magrin É Hôpital Necker-Enfants Malades, laboratoire de thérapie cellulaire génique, 75015 Paris, France.
  • Mamez AC Hôpitaux universitaires de Genève, laboratoire de thérapie cellulaire, 1211 Genève, Suisse.
  • Vaissié A CHU de Lille, plateforme de biothérapies, 59000 Lille, France.
  • Yakoub-Agha I Université de Lille, CHU de Lille, Infinite, U1286, Inserm, 59000 Lille, France.
  • Baudoux É CHU de Liège, thérapie cellulaire, 4000 Liège, Belgique. Electronic address: e.baudoux@chuliege.be.
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  • 2020-10-11
Published in:
  • Bulletin du cancer. - 2020
Allogeneic transplantation
Allogreffe de cellules souches hématopoïétiques
Boost
Boost CD34+
CD34 selection
Immunosélection CD34+
English CD34+ immunomagnetic positive selection allows for CD34+ hematopoietic progenitors separation from CD3+ lymphocytes subsets, usually from an apheresis product collected from a previously mobilized donor. This T-cell depleted stem cell graft is primarily intended for rare cases (around 2% of allotransplanted patients in France) of severe, persistent, symptomatic bi- or tri-cytopenia post-allotransplantation, in order to allow for hematologic reconstitution without increasing the risk of GvHD occurrence. Although semi-manual and complex, the process is of sufficient robustness to consistently generate a cellular product with distinctive features and specifications, based on iterative in-process quality controls, that are discussed within these guidelines.
Language
  • English
Open access status
closed
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Persistent URL
https://roar.hep-bejune.ch/global/documents/194602
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