Depletion of cutaneous macrophages and dendritic cells promotes growth of basal cell carcinoma in mice.
- König S Institute of Human Genetics, University Medical Center, Goettingen, Germany.
- Nitzki F Institute of Human Genetics, University Medical Center, Goettingen, Germany.
- Uhmann A Institute of Human Genetics, University Medical Center, Goettingen, Germany.
- Dittmann K Institute of Cellular and Molecular Immunology, University Medical Center, Goettingen, Germany.
- Theiss-Suennemann J Institute of Cellular and Molecular Immunology, University Medical Center, Goettingen, Germany.
- Herrmann M Department of Radiation Oncology, University Medical Center, Goettingen, Germany.
- Reichardt HM Institute of Cellular and Molecular Immunology, University Medical Center, Goettingen, Germany.
- Schwendener R Institute of Molecular Cancer Research, University of Zurich, Zurich, Switzerland.
- Pukrop T Department of Hematology and Oncology, University Medical Center, Goettingen, Germany.
- Schulz-Schaeffer W Department of Neuropathology, University Medical Center, Goettingen, Germany.
- Hahn H Institute of Human Genetics, University Medical Center, Goettingen, Germany.
- 2014-04-03
Published in:
- PloS one. - 2014
Animals
Carcinogenesis
Carcinoma, Basal Cell
Clodronic Acid
Dendritic Cells
Gene Expression Regulation, Neoplastic
Humans
Liposomes
Macrophages
Mice
Mice, Knockout
Mutation
Patched Receptors
Patched-1 Receptor
Receptors, Cell Surface
Skin Neoplasms
Tumor Microenvironment
English
Basal cell carcinoma (BCC) belongs to the group of non-melanoma skin tumors and is the most common tumor in the western world. BCC arises due to mutations in the tumor suppressor gene Patched1 (Ptch). Analysis of the conditional Ptch knockout mouse model for BCC reveals that macrophages and dendritic cells (DC) of the skin play an important role in BCC growth restraining processes. This is based on the observation that a clodronate-liposome mediated depletion of these cells in the tumor-bearing skin results in significant BCC enlargement. The depletion of these cells does not modulate Ki67 or K10 expression, but is accompanied by a decrease in collagen-producing cells in the tumor stroma. Together, the data suggest that cutaneous macrophages and DC in the tumor microenvironment exert an antitumor effect on BCC.
- Language
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- English
- Open access status
- gold
- Identifiers
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- DOI 10.1371/journal.pone.0093555
- PMID 24691432
- Persistent URL
- https://roar.hep-bejune.ch/global/documents/236770
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