Effect of roxithromycin on acute toxoplasmosis in mice.
- Chang HR Department of Microbiology, University of Geneva Medical School, Switzerland.
- Pechere JC
- 1987-07-01
Published in:
- Antimicrobial agents and chemotherapy. - 1987
Acute Disease
Animals
Disease Models, Animal
Female
Leucomycins
Mice
Random Allocation
Toxoplasmosis, Animal
English
Roxithromycin effectively treated acute peritoneal murine toxoplasmosis. After five doses, starting 24 h after challenge, the 100 and 50% survival doses were 540 and 336 mg/kg per day, respectively. After 14 doses, starting 3 h after challenge, the 50% survival dose was 360 mg/kg per day. Toxoplasma gondii was recovered from the brain in 59 and 28% of surviving mice treated with 5 and 14 doses, respectively.
- Language
-
- English
- Open access status
- bronze
- Identifiers
-
- DOI 10.1128/aac.31.7.1147
- PMID 3662475
- Persistent URL
- https://roar.hep-bejune.ch/global/documents/26047
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