Specific cellular responses to alpha-tocopherol.
- Azzi A Institute of Biochemistry and Molecular Biology, University of Bern, 3012 Bern, Switzerland.
- Breyer I
- Feher M
- Pastori M
- Ricciarelli R
- Spycher S
- Staffieri M
- Stocker A
- Zimmer S
- Zingg JM
- 2000-06-27
Published in:
- The Journal of nutrition. - 2000
Animals
Cell Adhesion
Cell Division
Diacylglycerol Kinase
Enzyme Activation
Humans
Lipoxygenase Inhibitors
Phosphoprotein Phosphatases
Platelet Aggregation
Protein Kinase C
Protein Phosphatase 2
Protein Processing, Post-Translational
Reactive Oxygen Species
Transcription, Genetic
Vitamin E
English
In the last 10 years precise cellular functions of alpha-tocopherol, some of which are independent of its antioxidant/radical-scavenging ability, have been revealed. Absorption of alpha-tocopherol from the gut is a selective process. Other tocopherols are not absorbed or are absorbed to a lesser extent. At the post-translational level, alpha-tocopherol inhibits protein kinase C and 5-lipoxygenase and activates protein phosphatase 2A and diacylglycerol kinase. Some genes [platelet glycoprotein IV/thrombospondin receptor/class B scavenger receptor (CD36), alpha-tocopherol transfer protein (alpha-TTP), alpha-tropomyosin, connective tissue growth factor and collagenase] are affected by alpha-tocopherol at the transcriptional level. alpha-Tocopherol also inhibits cell proliferation, platelet aggregation, monocyte adhesion and the oxygen burst in neutrophils. Other antioxidants, such as beta-tocopherol and probucol, do not mimic these effects, suggesting a nonantioxidant, alpha-tocopherol-specific molecular mechanism.
- Language
-
- English
- Open access status
- bronze
- Identifiers
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- DOI 10.1093/jn/130.7.1649
- PMID 10867030
- Persistent URL
- https://roar.hep-bejune.ch/global/documents/60188
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