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Increased capillary density in skeletal muscle is not associated with impaired insulin sensitivity induced by bed rest in healthy young men.
Journal article

Increased capillary density in skeletal muscle is not associated with impaired insulin sensitivity induced by bed rest in healthy young men.

  • Montero D a Department of Cardiology, University Hospital of Zurich, Switzerland.
  • Oberholzer L b Center for Physical Activity Research, University Hospital of Copenhagen, Denmark.
  • Haider T c Zurich Center for Integrative Human Physiology, Institute of Physiology, University of Zurich, Switzerland.
  • Breenfeldt-Andersen A d Department of Nutrition, Exercise and Sports, University of Copenhagen, Denmark.
  • Dandanell S c Zurich Center for Integrative Human Physiology, Institute of Physiology, University of Zurich, Switzerland.
  • Meinild-Lundby AK b Center for Physical Activity Research, University Hospital of Copenhagen, Denmark.
  • Maconochie H b Center for Physical Activity Research, University Hospital of Copenhagen, Denmark.
  • Lundby C b Center for Physical Activity Research, University Hospital of Copenhagen, Denmark.
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  • 2018-06-20
Published in:
  • Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme. - 2018
bed rest
capillarisation du muscle squelettique
glucose tolerance
insulin resistance
insulinorésistance
repos couché
skeletal muscle capillarization
tolérance au glucose
Adult
Bed Rest
Blood Glucose
Body Composition
Body Weight
Capillaries
Humans
Insulin Resistance
Male
Muscle, Skeletal
Neovascularization, Pathologic
Oxygen Consumption
Young Adult
English Physical inactivity alters glucose homeostasis in skeletal muscle, potentially developing into overt metabolic disease. The present study sought to investigate the role of skeletal muscle capillarization in glucose tolerance and insulin sensitivity (IS) using a classic human model of physical inactivity. Thirteen healthy males (age = 23 ± 2 years) underwent 4 days of full-time supervised and diet-controlled bed rest. Oral glucose tolerance test, indices of IS (quantitative insulin sensitivity check index (QUICKI), Matsuda index), as well as skeletal muscle biopsies with measurement of fiber type distribution, fiber cross-sectional area (FCSA), capillary-to-fiber ratio (C/F ratio), and capillary density (CD) were assessed prior to and after bed rest. Body weight and composition were unaltered by bed rest. Fasting glucose/insulin ratio (G0/I0 ratio) (-25%, P = 0.016), QUICKI (-7%, P = 0.023), and Matsuda index (-24%, P = 0.003) diminished with bed rest. Skeletal muscle FCSA decreased (-737.4 ± 763.2 μm-2 (-12%), P = 0.005) while C/F ratio was preserved, resulting in augmented CD (+93.9 ± 91.5 capillaries·mm-2 (+37%), P = 0.003) with bed rest. No association was detected between changes in skeletal muscle variables and metabolic outcomes. Independently of bed rest-induced effects, a positive linear relationship was detected between C/F ratio and G0/I0 ratio (β = 17.09, P = 0.021). In conclusion, impaired glucose homeostasis with bed rest is not prevented nor associated with enhanced skeletal muscle capillarization in healthy individuals.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://roar.hep-bejune.ch/global/documents/91445
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